Miles Morales takes up the mantle of Spider-Man! Before Peter Parker died, young Miles was poised to start the next chapter in his life in a new school. Then, a spider's bite granted the teenager incredible arachnid-like powers. Now, Miles has been thrust into a world he doesn't understand, with only gut instinct and a little thing called responsibility as his guides. Can he live up to Peter's legacy as Spider-Man? As Miles grapples with his new life, Miles' Uncle Aaron — A.K.A. the Prowler — learns his secret! He's got plans for his nephew, but little does he know that the Scorpion is on his tail! Plus: Universes collide, and the wall-crawlers of the Marvel and Ultimate Universes unite in the most ultimate, amazing Spider-Man story ever!